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In these trials, it is not clear if mTOR inhibition was achieved in the kidney or whether mTORC1 inhibition triggers a compensatory activation of mTORC2 limiting the beneficial effects of mTORC1 ( AMP-activated protein kinase (AMPK) AMPK is activated under conditions of metabolic and other cellular stresses (Steinberg and Hardie, 2022)

(2004) Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

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